Rejuran is a polynucleotide (PN) skin booster—specifically a polydeoxyribonucleotide (PDRN) derived from salmon DNA—injected intradermally to stimulate fibroblast activity, boost collagen production, and improve skin texture, hydration, and radiance. Unlike dermal fillers that add volume, Rejuran works as a biostimulator, triggering the skin's own regenerative machinery over 4–12 weeks post-treatment.
The product originated in South Korea and has dominated the Asian aesthetic market for over a decade, particularly in Korea, Japan, and Southeast Asia. It is manufactured by Dalim Biotech and marketed under the Rejuran brand (Rejuran Healer, Rejuran S, and Rejuran Eye). The mechanism centers on PDRN's ability to bind to adenosine receptors on fibroblasts, activating the A2A receptor pathway and upregulating hyaluronic acid synthesis, collagen I and III deposition, and anti-inflammatory cytokine expression.