South Dakota · Lenient

Can RNs and Nurse Practitioners Inject Botox in South Dakota?

Q: Can registered nurses and nurse practitioners inject Botox and fillers in South Dakota?

Yes, RN may inject under physician delegation NP/PA may practice and inject with physician collaboration; independent practice permitted in some settings

Nurses do most of the injecting in this industry — but South Dakota draws specific lines around what an RN versus an NP can do, and who has to supervise.

By Evan at Inside MedSpa

Registered nurses (RNs)

Yes, RN may inject under physician delegation

Nurse practitioners & physician assistants

NP/PA may practice and inject with physician collaboration; independent practice permitted in some settings

Supervision & the medical director

Not strictly required; physician oversight/delegation sufficient

The exam requirement

Required; in-person or telehealth allowed

What to verify in South Dakota

Establish clear delegation and telehealth protocols with your supervising physician to ensure compliance with state nursing and medical board standards.

Primary source: SD Medical Board, SD Board of Nursing

General business information for South Dakota medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the South Dakota board (and your own counsel) before you act.

See the full South Dakota regulation profile →

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