Who can inject
MD/DO, NP/PA under physician supervision, RN under physician delegation
Registered nurses (RNs)
Yes, under physician delegation; must be supervised by on-site or available physician
Nurse practitioners & physician assistants
NP/PA may inject only under physician supervision; independent practice prohibited
The exam that makes it legal
Required; in-person exam mandatory for initial visit A valid order or good-faith exam by an authorized provider is what makes an injection lawful — not simply who holds the syringe.
Training expected
No state-mandated injector training beyond licensure; however, physician oversight is mandatory.
What to verify in Illinois
Ensure your medical director is on-site or immediately available for all injection procedures and that all RN/NP/PA delegations are in writing.
Primary source: Illinois Department of Financial and Professional Regulation (IDFPR) / Medical Board
General business information for Illinois medical-spa owners, current as of 2026 — not legal advice. State boards update rules often; confirm specifics with the Illinois board (and your own counsel) before you act.